| Date | Location | Result | |
| 12/03/21 | Minneapolis, MN | Minnesota 3, South Dakota 0 (25-19,25-22,25-17) | Box score |
| 11/27/21 | Vermillion, SD | South Dakota 3, Omaha 0 (25-23,30-28,25-16) | Box score |
| 11/26/21 | Vermillion, SD | South Dakota 3, South Dakota St. 2 (20-25,25-18,25-20,24-26,18-16) | Box score |
| 11/20/21 | Fargo, ND | South Dakota 3, North Dakota St. 2 (25-16,23-25,25-18,15-25,18-16) | Box score |
| 11/18/21 | Grand Forks, ND | South Dakota 3, North Dakota 0 (25-16,25-19,25-18) | Box score |
| 11/14/21 | Vermillion, SD | Omaha 3, South Dakota 1 (25-27,25-15,25-23,25-21) | Box score |
| 11/11/21 | Vermillion, SD | South Dakota 3, Denver 2 (17-25,25-27,25-19,27-25,15-10) | Box score |
| 11/06/21 | Saint Paul, MN | South Dakota 3, St. Thomas (MN) 1 (20-25,25-15,25-13,25-23) | Box score |
| 11/04/21 | Macomb, IL | South Dakota 3, Western Ill. 0 (25-23,26-24,25-17) | Box score |
| 10/30/21 | Vermillion, SD | South Dakota 3, Oral Roberts 1 (25-20,25-22,19-25,25-12) | Box score |
| 10/28/21 | Vermillion, SD | South Dakota 3, Kansas City 1 (25-20,24-26,25-19,25-16) | Box score |
| 10/22/21 | Brookings, SD | South Dakota 3, South Dakota St. 1 (25-14,14-25,25-15,25-22) | Box score |
| 10/16/21 | Denver, CO | Denver 3, South Dakota 2 (12-25,20-25,25-13,25-17,15-10) | Box score |
| 10/14/21 | Omaha, NE | South Dakota 3, Omaha 2 (25-17,23-25,25-27,25-22,15-13) | Box score |
| 10/11/21 | Vermillion, SD | South Dakota 3, North Dakota 0 (25-14,25-14,25-17) | Box score |
| 10/09/21 | Vermillion, SD | South Dakota 3, Western Ill. 0 (25-14,25-20,25-18) | Box score |
| 10/07/21 | Sioux Falls, SD | South Dakota 3, St. Thomas (MN) 0 (25-21,25-11,25-18) | Box score |
| 10/02/21 | Kansas City, MO | South Dakota 3, Kansas City 2 (25-20,25-20,21-25,19-25,15-9) | Box score |
| 09/30/21 | Tulsa, OK | Oral Roberts 3, South Dakota 1 (25-19,17-25,25-19,25-18) | Box score |
| 09/28/21 | Vermillion, SD | South Dakota 3, North Dakota St. 0 (25-20,25-14,25-18) | Box score |
| 09/24/21 | Vermillion, SD | South Dakota 3, South Dakota St. 1 (19-25,25-12,25-22,25-18) | Box score |
| 09/18/21 | Wichita, KS | Wyoming 3, South Dakota 1 (22-25,25-23,25-21,25-19) | Box score |
| 09/18/21 | Wichita, KS | Creighton 3, South Dakota 0 (25-17,25-14,25-18) | Box score |
| 09/17/21 | Wichita, KS | Wichita St. 3, South Dakota 2 (25-18,22-25,25-20,18-25,15-13) | Box score |
| 09/10/21 | Vermillion, SD | South Dakota 3, Milwaukee 2 (25-21,21-25,15-25,25-16,15-12) | Box score |
| 09/10/21 | Vermillion, SD | South Dakota 3, Central Ark. 0 (29-27,25-20,25-22) | Box score |
| 09/09/21 | Vermillion, SD | South Dakota 3, Bradley 0 (25-17,25-20,27-25) | Box score |
| 09/05/21 | Louisville, KY | Missouri 3, South Dakota 1 (25-17,25-23,24-26,25-22) | Box score |
| 09/04/21 | Louisville, KY | Louisville 3, South Dakota 0 (25-15,25-12,25-15) | Box score |
| 09/03/21 | Louisville, KY | Northern Ky. 3, South Dakota 1 (11-25,25-23,25-21,25-18) | Box score |