| Date | Location | Result | |
| 03/26/22 | Wichita, Kan. (INTRUST Bank Arena) | Michigan 52, South Dakota 49 | Box score |
| 03/20/22 | Waco, Texas (Ferrell Center) | South Dakota 61, Baylor 47 | Box score |
| 03/18/22 | Waco, Texas (Ferrell Center) | South Dakota 75, Ole Miss 61 | Box score |
| 03/08/22 | Sioux Falls, S.D. (PREMIER Center) | South Dakota 56, South Dakota St. 45 | Box score |
| 03/07/22 | Sioux Falls, S.D. (PREMIER Center) | South Dakota 81, Kansas City 67 | Box score |
| 03/05/22 | Sioux Falls, S.D. (PREMIER Center) ) | South Dakota 75, Western Ill. 49 | Box score |
| 02/28/22 | Macomb, Ill. (Western Hall) | South Dakota 75, Western Ill. 48 | Box score |
| 02/26/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 78, Oral Roberts 49 | Box score |
| 02/24/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 71, Kansas City 49 | Box score |
| 02/17/22 | Saint Paul, Minn. (Schoenecker Arena) | South Dakota 73, St. Thomas (MN) 46 | Box score |
| 02/12/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 81, Denver 53 | Box score |
| 02/10/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 61, Omaha 35 | Box score |
| 02/05/22 | Brookings, S.D. (Sanford Coyote SC) | South Dakota St. 75, South Dakota 65 | Box score |
| 01/29/22 | Grand Forks, N.D. (The Betty) | South Dakota 88, North Dakota 72 | Box score |
| 01/27/22 | Fargo, N.D. (Scheels Center) | South Dakota 78, North Dakota St. 59 | Box score |
| 01/22/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 70, St. Thomas (MN) 43 | Box score |
| 01/20/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 70, Western Ill. 53 | Box score |
| 01/15/22 | Omaha, Neb. (Baxter Arena) | South Dakota 68, Omaha 45 | Box score |
| 01/13/22 | Denver, Colo. (Hamilton Gymnasium) | South Dakota 79, Denver 51 | Box score |
| 01/08/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 65, South Dakota St. 42 | Box score |
| 01/01/22 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 65, North Dakota St. 38 | Box score |
| 12/30/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 85, North Dakota 46 | Box score |
| 12/22/21 | Kansas City, Mo. (Swinney Center) | South Dakota 67, Kansas City 57 | Box score |
| 12/20/21 | Tulsa, Okla. (Mabee Center) | South Dakota 90, Oral Roberts 59 | Box score |
| 12/16/21 | Omaha, Neb. (Sokol Arena) | South Dakota 73, Creighton 71 | Box score |
| 12/10/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 51, Valparaiso 31 | Box score |
| 12/06/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 62, Bradley 39 | Box score |
| 12/04/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 71, Wichita St. 59 | Box score |
| 11/27/21 | St. Thomas, USVI (UVI Sports & Fitness) | South Dakota 72, Pittsburgh 61 (OT) | Box score |
| 11/26/21 | St. Thomas, USVI (UVI Sports & Fitness) | Texas A&M 58, South Dakota 44 | Box score |
| 11/25/21 | St. Thomas, USVI (UVI Sports & Fitness) | Northwestern 73, South Dakota 57 | Box score |
| 11/18/21 | Vermillion, S.D. (Sanford Coyote SC) | South Dakota 83, Briar Cliff (IA) 35 | Box score |
| 11/15/21 | Des Moines, Iowa (Knapp Center) | South Dakota 61, Drake 46 | Box score |
| 11/12/21 | Sioux Falls, S.D. (Sanford Pentagon) | South Carolina 72, South Dakota 41 | Box score |
| 11/09/21 | Vermillion, S.D. (Sanford Coyote SC) | Oklahoma 73, South Dakota 71 | Box score |