| Date | Location | Result | |
| Nov 19, 2022 | Vermillion, S.D. | UNI 58, South Dakota 14 | Box score |
| Nov 12, 2022 | Grand Forks, N.D. | North Dakota 28, South Dakota 19 | Box score |
| Nov 05, 2022 | Vermillion, S.D. | South Dakota 20, Missouri St. 13 | Box score |
| Oct 29, 2022 | Youngstown, Ohio | Youngstown St. 45, South Dakota 24 | Box score |
| Oct 22, 2022 | Vermillion, S.D. | South Dakota 27, Southern Ill. 24 | Box score |
| Oct 15, 2022 | Normal, Ill. | Illinois State 12, South Dakota 10 | Box score |
| Oct 08, 2022 | Brookings, S.D. | South Dakota St. 28, South Dakota 3 | Box score |
| Sep 24, 2022 | Vermillion, S.D. | North Dakota St. 34, South Dakota 17 | Box score |
| Sep 17, 2022 | Vermillion, S.D. | South Dakota 38, Cal Poly 21 | Box score |
| Sep 10, 2022 | Missoula, Mont. | Montana 24, South Dakota 7 | Box score |
| Sep 03, 2022 | Manhattan, Kan. | Kansas State 34, South Dakota 0 | Box score |