| Date | Location | Result | |
| Nov 27, 2021 | Vermillion, S.D. | Southern Illinois 22, South Dakota 10 | Box score |
| Nov 20, 2021 | Fargo, North Dakota | North Dakota State 52, South Dakota 24 | Box score |
| Nov 13, 2021 | Vermillion, S.D. | South Dakota 23, South Dakota State 20 | Box score |
| Nov 06, 2021 | Macomb, Ill. | South Dakota 42, Western Illinois 21 | Box score |
| Oct 23, 2021 | Vermillion, S.D. | Illinois State 20, South Dakota 14 | Box score |
| Oct 16, 2021 | Cedar Falls, Iowa | South Dakota 34, UNI 21 | Box score |
| Oct 09, 2021 | Vermillion, S.D. | South Dakota 20, North Dakota 13 | Box score |
| Oct 02, 2021 | Vermillion, S.D. | South Dakota 38, Indiana State 10 | Box score |
| Sep 25, 2021 | Springfield, Mo. | Missouri St. 31, South Dakota 23 | Box score |
| Sep 18, 2021 | San Luis Obispo, CA | South Dakota 48, Cal Poly 14 | Box score |
| Sep 11, 2021 | Vermillion, S.D. | South Dakota 34, Northern Arizona 7 | Box score |
| Sep 03, 2021 | Lawrence, Kan. | Kansas 17, South Dakota 14 | Box score |