| Date | Location | Result | |
| Nov 13, 2010 | Beaumont, Texas | Lamar 24, South Dakota 20 | Box score |
| Nov 06, 2010 | Vermillion, S.D. | Cal Poly 38, South Dakota 24 | Box score |
| Oct 30, 2010 | Vermillion, S.D. | South Dakota 34, Northern Colorado 6 | Box score |
| Oct 23, 2010 | Cedar City, Utah | Southern Utah 31, South Dakota 13 | Box score |
| Oct 16, 2010 | Vermillion, S.D. | Northern Iowa 19, South Dakota 14 | Box score |
| Oct 09, 2010 | Davis, Calif. | UC Davis 17, South Dakota 13 | Box score |
| Oct. 2, 2010 | Vermillion, S.D. | South Dakota 27, North Dakota 17 | Box score |
| Sep 25, 2010 | Fargo, ND | North Dakota State 38, South Dakota 16 | Box score |
| Sep 18, 2010 | Vermillion, S.D. | South Dakota 48, NW Oklahoma State 14 | Box score |
| Sep 11, 2010 | Minneapolis, Minn. | South Dakota 41, Minnesota 38 | Box score |
| Sep 04, 2010 | Orlando, Fla. | Central Florida 38, South Dakota 7 | Box score |