| Date | Location | Result | |
| Nov 11, 2000 | Vermillion, S.D. | South Dakota 24, Minn St, Mankato 3 | Box score |
| Nov 04, 2000 | Brookings, S.D. | South Dakota 41, South Dakota State 28 | Box score |
| Oct 28, 2000 | Sioux City, Iowa | South Dakota 30, Morningside 7 | Box score |
| Oct 21, 2000 | Vermillion, S.D. | South Dakota 27, Northern Colorado 6 | Box score |
| Oct 13, 2000 | Vermillion, S.D. | Nebraska-Omaha 21, South Dakota 7 | Box score |
| Oct 07, 2000 | St. Cloud, Minn. | South Dakota 37, St. Cloud State 0 | Box score |
| Sep 30, 2000 | Vermillion, S.D. | South Dakota 15, Augustana 10 | Box score |
| Sep 23, 2000 | Fargo, N.D. | North Dakota State 45, South Dakota 20 | Box score |
| Sep 16, 2000 | Grand Forks, N.D. | North Dakota 42, South Dakota 14 | Box score |
| Sep 09, 2000 | Vermillion, S.D. | South Dakota 38, Truman State 14 | Box score |
| Aug 31, 2000 | St. Joseph, Mo. | South Dakota 17, Missouri Western St 13 | Box score |